In terms of holiday weather impact, the Pacific Northwest and Northern Rockies are the areas where travel on Wednesday will have impacts thanks to a larger scale storm system. Outside of a few showers or storms in West Texas and New Mexico, the rest of the country looks to be rather dry and tranquil for travel on Wednesday, which is one of the busiest holiday travel days for the year.
Shifting to Thanksgiving itself, the weather across the eastern third of the country remains dry as high pressure sits overhead. Showers are possible out in advance of the storm system in the Northwest's advance through the country. Those showers shouldn't be terribly widespread as the cold front pushes east. The front itself will be pretty dry. Snow straddles the Canadian border in Minnesota and North Dakota but the rest of the country is dry.